Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. Bogdanich, W.; McLean, R. "Poisoned Toothpaste in Panama Is Believed to Be From China". It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. High boiling point. Once DEG reaches the liver, it is metabolized by enzymes. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. [71][72], InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, InChI=1/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, Except where otherwise noted, data are given for materials in their, 1937 – The Massengill Incident (United States). Furthermore, it is also found in domestic detergents and brewing chemicals. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. stated in. [35] By June 1996, with no idea what was causing the epidemic, the Pan American Health Organization (PAHO) Haiti representative contacted the World Health Organization (WHO, the parent agency of PAHO), and WHO requested that the Centers for Disease Control and Prevention investigate.[36][29][37]. Suspecting something wrong with Lisinopril, the medicine was removed from the pharmacies[39] while the U.S. Food and Drug Administration conducted lab analyses, revealing the blood pressure drug was safe; CDC epidemiologists were then invited to participate. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. Diethylene Glycol Ether Factory Offer High Grade 99% Butyldiglycol/ Diethylene Glycol Monobutyl Ether Cas 112-34-5 US $2.00-$5.00 / Kilogram 1.0 Kilograms (Min Order) Bogdanich, W. "Wider Sale Is Seen for Toothpaste Tainted in China ", U.S. Bureau of Alcohol, Tobacco and Firearms, Centers for Disease Control and Prevention, "Toxic alcohol ingestions: clinical features, diagnosis, and management", ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN: Polyethylene glycol, Existing Chemical Hazard Assessment Report, Australian Competition and Consumer Commission, "Toothpaste containing more than 0.25 per cent by weight of diethylene glycol (DEG)". Diethylene Glycol Monobutyl Ether poisoning symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether poisoning (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. The industry generally operates to maximize MEG production. [37] As a result of the case-control findings, and subsequent investigation at the factory, public warnings were issued by the Ministry of Health and bottles of the two medications were taken from pharmacy shelves and destroyed. "FDA Advises Consumers to Avoid Toothpaste From China Containing Harmful Chemical. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. More commonly known as Diethylene Glycol Monoethyl Ether. In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. I, the copyright holder of this work, hereby publish it under the following licenses: The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. They react with oxoacids and carboxylic acids to … Our team of experts are at the ready. [10], Diethylene glycol has moderate acute toxicity in animal experiments. Once verifying that he was fine, he shipped it to Qiquihar No. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. [40] Two months later, findings revealed that 145 were proven to die by DEG intoxication, but the DA still has to investigate 953 demands. Draw with ChemBioDraw Ultra 12.0. They also arrested 12 people in connection with the incident. They react with oxoacids and carboxylic acids to … Postmortem examination revealed damage in the kidneys and liver, and laboratory testing found DEG instead of propylene glycol in the sedatives. Following restrictive measures decided by one Member State on the basis of Article 12 of Directive 76/768/EEC regarding the use of diethylene glycol monobutyl ether (DEGBE) and ethylene glycol monobutyl ether (EGBE) in cosmetic products, the SCCP was consulted. ", "Scandal over poisoned wine embitters village in Austria.". 86-13. Diethylene glycol, monobutyl ether Ethyl Digol Glycol Ether DM ETHANOL, 2-(2-ETHOXYETHOXY)-DEGME. Mr. Wang was caught and Qiquihar was shut down by the authorities. Promotes uniform dispersion; translucent to clear. [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. Besides Wang, five employees of Qiquihar were prosecuted. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. Fourteen patients received hemodialysis, but the treatment failed. [1], DEG is produced by the partial hydrolysis of ethylene oxide. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. It was not until September 1996 that Sinochem provided a name of the manufacturer of the tainted syrup. DEGEE. [11] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. Depending on the conditions, varying amounts of DEG and related glycols are produced. [49][50][51] For the end of the month, the Chinese government committed to investigate the “supposedly” tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. Authorities warn against using some toothpastes, Taste of Raspberries, Taste of Death – The 1937 Elixir Sulfanilamide Incident, "Wallace Reveals How Federal Agents Traced Elixir to Halt Fatalities", "Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination", "Popular Wines found to hold toxic chemical. DEG is a widely used solvent. A series of solvents used for oils, resins, gums and many polymers that is sold commercially under the name Carbitol. Unfortunately, Taixing used “TD” for the Chinese word tidai, meaning “substitute”. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Siegfried Rebsdat and Dieter Mayer "Ethylene Glycol" in Ullmann’s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. * * 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. BACKGROUND A risk assessment of DEGBE with the chemical name 2-(2-butoxyethoxy)ethanol or diethylene glycol monobutyl ether was done by a member state (France). Carbitol These measures quickly ended the advance of the epidemic. Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. AICS Chemical ID. Industry Circular No. [58], In July 2007, health authorities in the UK detected a counterfeit Sensodyne toothpaste on sale at a car boot sale in Derbyshire. [14][15], In 1937, S.E. UNII. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 9: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. [1] DEG is a widely used solvent. Synonyms and Related Terms. [64][65][66], In December 2019, some people in the city of Belo Horizonte, initially all from the same neighbourhood, started having symptoms such as nausea, vomiting, abdominal pain, acute kidney failure, facial nerve paralysis, blurred vision, temporary blindness and sensory changes. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. [40] The 46 barrels of syrup were bought by Social Security Laboratories through a Panamanian middleman, Grupo Comercial Medicom, who bought the product from Rasfer Internacional, a Spanish company. [1] In personal care products (e.g. 0 references. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. Dermal absorption is very low, unless it is administered on broken or damaged skin. Diethylene glycol monobutyl ether Valid: TSCA Inv Ethanol, 2-(2-butoxyethoxy)- Valid: CAA 111 Diethylene glycol monobutyl ether Valid: 01/05/1981: CAA112(b) HAP Diethylene Glycol Monobutyl Ether Unknown: Pesticide Tolerance Exemptions Diethylene glycol mono butyl ether Unknown Record Status: Validated (UNII) … Barewa Pharmaceuticals was shut down and the product was pulled off the shelves. [11] The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body,[12] but the accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. [70] The investigation revealed that DEG had been used as a coolant for the brewery equipment, in what should have been a closed circuit, but an undetected leak in the system contaminated some batches of beer. The death rate of this mysterious illness was nearly 50%, when hospital management decided to isolate all the patients with the illness in a large room and doctors could compare notes and theories. [67] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. Once he was inside, there was nothing to do: the plant had already been shut down. It is supplied as a urethane grade solvent. Panama awaits the extradition of Criado for her hearing. It is also used in printing inks when very slow drying is desired. Unique Ingredient Identifier. Alibaba.com offers 101 diethylene glycol monobutyl ether products. At the time, the food and drug laws did not require toxicological analysis before releasing for sale. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. Some time later, Wang found a reference to diethylene glycol in a chemical book. In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. Jean-Claude Bradley Open Melting Point Dataset, NFPA 704: Standard System for the Identification of the Hazards of Materials for Emergency Response, InChI=1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3, Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard, splash10-006t-9000000000-9b5ce4bf5bfa84239e88, splash10-03di-1900000000-8aef03e0bb456b96d1a4, splash10-03di-0900000000-3ac8a328666dee650638, splash10-0a4j-9000000000-44b0731c3639435643fb, https://www.wikidata.org/w/index.php?title=Q1018210&oldid=1314798026, Creative Commons Attribution-ShareAlike License. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Soon, patients from other parts of the country started to arrive at hospitals. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. Packaging 1, 4 L in poly bottle 18 L in steel drum Legal Information Product of Dow Chemical [29] The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. Some authors suggest the minimum toxic dose is estimated at 0.14 mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[1] and others suggest this is the LD30. Diethyl Glycol Monobutyl Ether. in textile processing and serves as an intermediary product in the chemical industry. With the available technology of the era, the CDC determined the glycerin used in the syrup preparation was contaminated with approximately 24% DEG. Reference: 1. [39], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. [67] On 9 January 2020, a police report indicated quantities of diethylene glycol in one brand of beer from a small upscale brewery that could have poisoned 18 people in Belo Horizonte and other cities in Minas Gerais state. [16][17][18] This episode was the impetus for the Federal Food, Drug, and Cosmetic Act of 1938. Incidents include its use in China as a component of cheap toothpaste, and by winemakers in Europe as an adulterant to create a "sweet" wine. FDA Detains One Contaminated Shipment, Issues Import Alert", June 1, 2007. Laboratory testing at CDC of samples taken from parents revealed significant contamination with DEG. Internal Medicine Residency Program of the College of Medicine of Wake Forest University, North Caroline, U.S.A. English: Structure of Diethylene glycol monobutyl ether acetate. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. This event caused the death of five patients.[3][21][22]. Panamanian officials traced the toothpaste to a local company in the Colón Free Trade Zone. [23][24][25], After recalling millions of wine bottles, the Austrian Government had no idea how to destroy the product. 9TB90IYC0E. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. The prognosis depends on prompt diagnosis and treatment due to the high mortality rate DEG intoxication produces. Because patients treated with Lisinopril developed a cough (a common side effect of ACE inhibitors), they were prescribed an expectorant. [61], Ending November 2008, infants started to die after developing unexplained fevers and vomiting. For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. Testing of medication samples taken from the factory samples by both CDC and by an independent commercial lab located in Miami, revealed contamination by DEG of 16.4% and higher. [19] This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. [3] The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. Diethylene glycol monobutyl ether is used as a solvent in paints and varnishes e.g. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. About Diethyl Glycol Monobutyl Ether Enquire Now. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. diethylene glycol monobutyl ether (English) retrieved. Notice of Adoption to Text of Regulations Title 22, Amendment to Section 12805 Maximum Allowable Dose Levels (MADLs) for Ethylene Glycol Monoethyl Ether (EGEE), Ethylene Glycol Monoethyl Ether Acetate (EGEEA), and Potassium Dimethyldithiocarbamate , S.E all structured data from the main, Property, Lexeme, and plasticizers Taixing used TD. All structured data from the main, Property, Lexeme, and plasticizers various liquid crystals diverse health problems for... By jet to CDC for analysis between ages of two months and seven years as a solvent for nitrocellulose resins... 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