Manifestations of acute butoxyethanol toxicity include metabolic acidosis, hemolysis, hepatorenal dysfunction, and coma, but vary widely in reported cases. 603-014-00-0. What happens to 2-butoxyethanol and 2-butoxyethanol acetate when it enters the environment? This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. There are no data on whether butoxyethanol causes reproductive effects, birth defects, or cancer in people, according to ATSDR. Working in occupations such as silk-screening, printing, Though it can also be found in household cleaners. 2-Butoxyethanol. It is imported for use mainly as a component of formulations, as part of consumer products or manufactured articles, and as a chemical processing aid. 2-Butoxyethanol and 2-butoxyethanol acetate may break 2-Butoxyethanol. This toxic chemical is mainly found in the kitchen, in glass and multi-purpose cleaners. In air, 2-butoxyethanol and 2-butoxyethanol acetate may Toxic substances list: 2-butoxyethanol. 2-Butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer.” Living near a hazardous waste site where 2-butoxyethanol 111-76-2. It can harm the eyes, skin, kidneys, and blood. Background: Severe toxic ingestions of butoxyethanol (CAS No. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, 2-Butoxyethanol and 2-Butoxyethanol Acetate. Exposures near the lethal level caused systemic toxicity in the form of hemoglobinuria and lung, kidney, and liver changes. Read more: Understanding Risk and Hazard When it Comes to Chemicals, butoxyethanol is safe in hair and nail products, U.S. Agency for Toxic Substances & Disease Registry (ATSDR). Email: Contact CDC-INFO. How can 2-butoxyethanol and 2-butoxyethanol acetate affect my health? Many people are exposed to small amounts of 2-butoxyethanol How to avoid 2-Butoxyethanol For this reason, some items on this page will be unavailable. Butoxyethanol is a solvent in spray lacquers, enamels, varnishes, and latex paints due to its ability to clean grease and dirt. You may have seen 2-Butoxyethanol as Ethylene Glycol Monobutyl Ether, Butyl Glycol, Butyl Oxitol, or Glycol Butyl Ether and more. A colorless liquid with a sweet scent, butoxyethanol is primarily used in paints and coatings, and also is an ingredient some household cleaning products, cosmetics and personal care products. Articles of 2-butoxyethanol are included as well. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. 2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH (Bu = CH3CH2CH2CH2). No evidence of genotoxicity was seen in a battery of tests with metabolic activation, but positive and negative effects were seen in the absence of metabolic activation. Since it is significantly less toxic as compared to ethylene glycol, propylene glycol is the preferred antifreeze used in motor homes and recreational vehicles. Hemolysis, a primary toxic effect associated with 2-butoxyethanol exposure in rodents, increased hemosiderin (iron) deposition in Kupffer cells … Those could include breathing problems, low blood pressure, lowered levels of hemoglobin, blood in the urine, and metabolic acidosis (high levels of acid in the body). Is there a medical test to show whether I've been exposed to 2-butoxyethanol and 2-butoxyethanol acetate? Workers may be harmed from exposure to 2-butoxyethanol. To help protect workers who use butoxyethanol in occupational settings, the U.S. Occupational Safety and Health Administration (OSHA) has set an exposure limit of 50 parts of 2-butoxyethanol per million parts of air (50 ppm) for an 8-hour workday, 40-hour workweek. Eye irritation. The level of exposure depends upon the dose, duration, and work being done. The safety of Butoxyethanol has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. Butoxyethanol helps decrease the overall thickness of a varnish or paint to help enable smoother application. Use restrictions (moderate), Non-reproductive organ system toxicity (low), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high) fragrance ingredient, solvent, viscosity decreasing agent, masking, and viscosity controlling Butoxyethanol is an ether alcohol. It is advertised as an environmentally friendly, non-toxic, and biodegradable cleaner. 2-Butoxyethanol is widely used as a solvent in protective surface coatings such as spray lacquers, quick-dry lacquers, enamels, varnishes, and latex paints. Learn more about the chemistry in the products we rely on every day, including how and why particular chemicals are used in different products, and health and safety information about these chemicals. Maybe if you’re exposed to a chemical a handful of times it wouldn’t cause harm, but some chemicals build up enough or cause enough harm in your body over time that it triggers some kind of disease outcome. Butoxyethanol also can help keep a substance clear—even after a product is exposed to extreme temperatures during shipping or storage. 2-Butoxyethanol - Identification, toxicity, use, water pollution potential, ... PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. As the Centers for Disease Control and Prevention notes, exposure to 2-Butoxyethanol can harm your eyes, skin, kidneys, and blood. Sutton explains: “Our concern is daily, weekly, chronic exposure over a lifetime. Cleaning products with butoxyethanol can be effective in cleaning grease and dirt, and can be used safely by following instructions on a product’s label. 2-butoxyethanol and 2-butoxyethanol acetate. NOTE! 2-Butoxyethanol and 2-butoxyethanol acetate may be released low U.S. Environmental Protection Agency. 888-232-6348 (TTY) Because this product can work as a surfactant, it is able to … 2-Butoxyethanol Petroleum Uses This product is an essential component of fracturing fluids, drilling stabilizers, and oil slick dispersants for water-based and oil-based hydraulic fracturing. 1-3, p. 71). U.S. Agency for Toxic Substances & Disease Registry, U.S. Occupational Safety and Health Administration. 2-Butoxietanol When tested undiluted, 2-butoxyethanol is a severe eye irritant (CICAD 1998). How might I be exposed to 2-butoxyethanol and 2-butoxyethanol acetate? Compare Products: Select up to 4 products. 2-Butoxyethanol increases hemangiosarcomas selectively in male mouse liver after chronic inhalation through mechanisms that have not fully been elucidated. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. Skin irritation. A U.S. Environmental Protection Agency review finds 2-butoxyethanol is not toxic to reproduction or development. According to the U.S. Agency for Toxic Substances & Disease Registry (ATSDR), inappropriately or accidentally swallowing large amounts of cleaning agents containing butoxyethanol can cause harmful effects for people. and automobile repair shops that use materials containing The CIR Expert Panel reviewed the scientific data and concluded that Butoxyethanol is safe in hair and nail products at concentrations up to 10.0%. *Please select more than one item to compare HP4 Irritant — skin irritation and eye damage: waste which on application can cause skin irritation or damage to the eye. Butoxyethanol is also regulated under the Clean Air Act, including the National Emission Standards for Hazardous Air Pollutants. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. These compounds enhance the dispersion of oil by reducing … Chemsrc provides 2-butoxyethanol(CAS#:111-76-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Breathing in large amounts of 2-butoxyethanol or 2-butoxyethanol acetate may result in irritation of the nose and eyes, headache, and vomiting. It is usually produced by a reaction of ethylene oxide with butyl alcohol, but it may also be made by the reaction of ethylene glycol with dibutyl sulfate. 2-butoxyethanol; ethyleneglycol monobutyl ether; butyl cellosolve. It's used a a solvent in paint strippers, thinners. Butoxyethanol was only slightly toxic in an acute oral study in rats and in a dermal study in rabbits. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. This chemical is known by many different names, which are a mouthful, to say the least. Breathing air or having skin contact with household cleaners Use the search box to find information on the chemicals that are essential to the products you use every day. Note: Javascript is disabled or is not supported by your browser. 2-Butoxyethanol. 2-Butoxyethanol is not currently produced in Canada. Has the federal government made recommendations to protect human health? It is imported for use mainly as a component of formulations, as part of consumer products or manufactured articles, and as a chemical processing aid. Both compounds may pass into air from water and soil. Overview. Exposure to 2-butoxyethanol and butoxyethanol acetate occurs mainly from breathing air or having skin contact with household products containing them. Based on the National Pollutant Release Inventory (NPRI), most reported environmental releases are to the atmosphere, with some minor releases to water. These could include breathing problems, low blood pressure, lowered levels of hemoglobin, blood in the urine, and metabolic acidosis (high levels of acid in the body). Butyl Cellosolve (CAS #111-76-2 also known as Butyl Cellusolve, Butoxyethanol, Butyl Glycol and Ethylene Glycol Monobutyl Ether) is a toxic agent used in many industrial and domestic cleaners – many of which claim to be non-hazardous.It is absorbed through the skin and lungs causing a variety of health issues depending on the level of exposure. 2. Butoxyethanol, also known as 2-Butoxyethanol, is a widely used solvent. 2-Butoxyethanol (C ₄ H ₉ OCH ₂ CH ₂ OH) is a colorless liquid with a mild odor. How likely is 2-butoxyethanol and 2-butoxyethanol acetate to cause cancer? 2-Butoxyethanol is moderately toxic via the oral and dermal routes of exposure and it is of low toxicity via the inhalation route of exposure. into the air when they are used as solvents and in household The Cosmetic Ingredient Review (CIR), an expert scientific panel sponsored by the Personal Care Products Council has assessed the safety of butoxyethanol in personal care products, concluding that butoxyethanol is safe in hair and nail products at concentrations at low levels (<10%) – per CIR’s recommendation. These clinics specialize in Print From all the studies, no specific relevant toxic effects, other that haemotoxicity, can be identified that are clearly related to treatment with 2 -butoxyethanol. products. Some harmful effects of 2-butoxyethanol have been seen in animals such as rats and rabbits. It is a known respiratory irritant and can be acutely toxic but animal studies did not find it to be mutagenic, and no studies suggest it is a human … and 2-butoxyethanol acetate are disposed of. The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. When inhaled, 2-Butoxyethanol can cause sore a throat. As with other cleaning products, keep household products containing 2-butoxyethaol out of the reach of children to avoid accidental ingestion. The compound is classified as glycol ether, a group of powerful solvents that should not be toyed with. Print this Page. be removed by rain, ice, or snow. When tested undiluted, 2-butoxyethanol is a severe skin irritant. For using cleaning products containing butoxyethanol in the home, follow safe handling instructions included on the label to minimize potential exposure. 4 Skin Irrit. HP6 Acute Toxicity: waste which can cause acute toxic effects following oral or dermal administration, or inhalation exposure. Other glycol ethers, such as EGME/EGBE, are a group of compounds that are used as organic solvents in various products. ATSDR can also tell you the location of occupational and environmental health clinics. down in air into other compounds within a few days. furniture production and finishing, spray-painting operations, Diethylene glycol is used in numerous products including solvents and brake fluids. 2-Butoxyethanol is a colorless liquid with a mild odor. What is 2-butoxyethanol and 2-butoxyethanol acetate? 2-Butoxyethanol is not currently produced in Canada. [1] [3] It is also associated with asthma and allergies. y Acetato de 2-Butoxietanol, Toxicological Profile for 2-butoxyethanol and 2-butoxyethanol acetate, Agency for Toxic Substances and Disease Registry. On importe le 2-butoxyéthanol pour utilisation comme ingrédient de formulations, de produits de consommation ou d'articles fabriqués, ainsi que comme adjuvant de traitements chimiques. 2-Butoxyethanol … According to the U.S. Agency for Toxic Substances & Disease Registry (ATSDR), inappropriately or accidentally swallowing large amounts of cleaning agents containing butoxyethanol can cause harmful effects for people. Other reproductive effects and birth defects in animals have only been observed at doses that were toxic to the adult animals." Common household cleaning products like glass cleaners, liquid soaps and all-purpose spray-cleaners contain butoxyethanol, for its ability to help dissolve substances such as grease and dirt. Cosmetic products such as hair dyes, nail polishes, nail polish removers and skin cleansers contain butoxyethanol, which can help prevent the other product ingredients from separating within the formulation. Search results for butoxyethanol at Sigma-Aldrich. For risk characterisation purposes therefore, haemotoxicity will be the end point chosen keeping in mind the interspecies differences (human/rodents) to calculate margin of safety. 2-Butoxyethanol and 2-butoxyethanol acetate do not build Exposures to butoxyethanol are more likely to occur in the workplace, for example in spray-painting operations or automobile repair shops, rather than in the environment or at home. 2-Butoxyethanol has long been known to be toxic, with early studies indicating that a single seven-hour exposure to 700 ppm was lethal to laboratory animals (Werner, Mitchell, Miller, and von Oettingen 1943a, as cited in ACGIH 1986/Ex. 2-Butoxyethanol is a clear colorless liquid that smells like ether. 2-Butoxyéthanol France (VLEP contraignante) 10 49 50 246 2-Butoxyéthanol Allemagne (valeurs MAK) 10 49 - - 2-Butoxyéthanol États-Unis (ACGIH) 20 97 - - Méthodes de détection et de détermination dans l'air Intermédiaire de synthèse organique, notamment pour la fabrication de l'acétate de 2-butoxyéthyle. D'après l'Inventaire national des rejets de polluants (INRP), la plupart des rejets déclarés dans l'environnement se font vers l'atmosphère, hormis quelques rejets dans l'eau. Don’t use Butyl Cellosolve. This toxic body burden is EWG’s chief concern about household chemicals. Those could include breathing problems, low … up in plants and animals. or other liquids that contain these compounds. Butoxyethanol is also regulated under the Clean Air Act, including the National Emission Standards for Hazardous Air Pollutants. The National Emission Standards for Hazardous Air Pollutants regulates 2-butoxyethanol under the Clean Air Act because it has demonstrated the potential to cause serious health issues including reduced fertility, low birth weight and toxic liver metabolites. 203-905-0. You can normally find 2-Butoxyethanol in window and kitchen cleaners. Butoxyethanol was nephrotoxic in an intravenous study in rats, but not when administered intraperitoneally. The CIR found that even at the maximum concentration of 10 percent, water-based butoxyethanol did not cause skin irritation in a patch test involving 201 subjects. According to ATSDR, inappropriately or accidentally swallowing large amounts of cleaning agents containing butoxyethanol can cause harmful effects. This is the compound that gives many cleaners a sweet smell. 111-76-2) are rare despite the prevalence of this glycol ether in products such as glass and surface cleaners. No studies have been found that tested butoxyethanol for causing cancer in animals, according to ATSDR. 2010. 2-Butoxyethanol in the environment comes from some industrial activities. One of the main industrial uses of butoxyethanol is as a solvent in protective surface coatings, such as spray lacquers, quick-dry lacquers and enamels, as well as water-based varnishes and latex paints. SCA endorses products with the Toxic-Free Tick, that do not contain butoxyethanol CAS 111-76-2. “2-Butoxyethanol is readily absorbed following inhalation, oral, and dermal exposure. The EPA has identified this chemical as especially hazardous when inhaled. and 2-butoxyethanol acetate every day. It is also a common ingredient in in liquid soaps and cosmetics, as well as industrial and household cleaning products. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Butoxyethanol is also an ingredient in adhesives and inks used on food packaging. It received critical attention from environmental safety activists because of the toxicity concerns of 2-butoxyethanol (EGBE), which was in the formula at under 4%. 2-Butoxyethanol has been found in at least 20 of the 1,430 National Priorities List sites … Acute Tox. 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